Сравнительный анализ динамики показателей качества жизни у больных хронической обструктивной болезнью легких на фоне вакцинации против пневмококковой инфекции с использованием 13-валентной конъюгированной и 23-валентной полисахаридной вакцин

The aim of this study was to evaluate an impact of 13-valent conjugate pneumococcal vaccine (PCV-13) and 23-valent polysaccharide pneumococcal vaccine (PPV-23) on quality of life of patients with chronic obstructive pulmonary disease. Methods. We estimated quality of life from baseline to 12 months after the vaccination using the COPD Assessment Test (CAT). Results. The study involved 58 patients with COPD vaccinated with PCV-13 (n = 33) or PPV-23 (n = 25). The CAT score reduced by 10.3 in patients vaccinated with PCV-13 and by 8.8 in patients vaccinated with PPV-23 (p < 0.05). Conclusion. Vaccination of COPD patients with PCV-13 or PPV-23 could significantly improve quality of life. The conjugate vaccine PCV-13 is more preferable. Further studies of microbiological, immunological and other effects of PCV-13 and PPV-23 in COPD patients are needed.