Somatostatin and insulin release from isolated rat pancreatic islets in response to D-glucose, L-leucine, α-ketoisocaproic acid or D-glyceraldehyde: Evidence for a regulatory role of adenosine-3′,5′-cyclic monophosphate

Abstract Somatostatin and insulin release from isolated rat pancreatic islets was stimulated by glucose, leucine or α-ketoisocaproic acid. D-glyceraldehyde stimulated insulin release but diminished the secretion of somatostatin. Glucagon and theophylline amplified the glucose-induced somatostatin release. A regulatory role of the D-cell's adenylate cyclase/phosphodiesterase system for the release of somatostatin is suggested. Furthermore, stimulation as well as inhibition of somatostatin release might be of significance for the secretory function of the B-cell.