P33 Bone mineral density in cystic fibrosis children in saint petersburg

Background Bone mineral disturbances are often complication of the cystic fibrosis (CF) patients with impact linear growth, quality of life and life expectation and may be contraidication for lung transplant. Osteoporosis is a complex multifactorial diseases which started in the childhood. The aim of our study was to evaluate bone mineral metabolism in CF children in the Saint-Petersburg. Materials In the present study 57 CF children, aged 5–18 years were included. For assessment of bone health we evaluated: i) number of significant fractures; ii) dual-energy X-ray absorptiometry (Lunar iDXA 16[SP2]) with pediatric database in lumbar spine (L1–L4) and in total body less head (TBLH); iii) bone age with Greulich-Pyle method; iiii) Tanner’s puberty stage and anthropometry. In the cases with significant growth delay or acceleration the height- or biologic age standardization for bone mineral density (BMD) applied Results The BMD Z score -1SD to - 2SD was in 15 (26.3%) children and Z score Conclusion We have not found osteoporotic CF patients. Further investigations required for cystic fibrosis patients with borderline decreased bone mineral density (near or less than -2 SD).