Activated platelet chemiluminescence and presence of CD45+ platelets in patients with acute myocardial infarction

AbstractIt has been found that in 15% of acute myocardial infarction patients’ platelets generate reactive oxygen species that can be detected with luminol-enhanced chemiluminescence of platelet-rich plasma within 8–10 days after acute myocardial infarction. This increase in generate reactive oxygen species production coincides with the emergence of CD45+ platelets. The ability of platelets to carry surface leukocyte antigen implies their participation in exchange of specific proteins in the course of acute myocardial infarction. Future studies of CD45+ platelets in peripheral blood of acute myocardial infarction patients in association with generate reactive oxygen species production may provide a new insight into the complex mechanisms of cell–cell interactions associated with acute myocardial infarction.