Estimation of dietary intake of cadmium from cadmium in blood or urine in East Asia

Abstract Background and aim Cadmium (Cd) is an ubiquitous environmental toxic pollutant. As daily foods are an almost exclusive source of exposure for general populations, it is of public health importance to know the level of dietary intake of cadmium (Cd-D). The purpose of this study is to examine whether Cd in blood (Cd-B) or urine (Cd-U) correlates with Cd-D in East Asia, and in case it is, whether it is possible to estimate Cd-D from Cd-B or Cd-U. It should be added that the measurement of Cd-D is quite hand-consuming in practice. Materials and methods Literature was retrieved for publication on Cd-B and Cd-U in combination with Cd-D. Twenty three data sets thus obtained for East Asia were subjected to regression analysis to investigate the possibility to estimate Cd-D from Cd-B or Cd-U. Results In Japan and Korea, large correlation coefficients (p > 0.7) were observed between Cd-B and Cd-D, as well as between Cd-U and Cd-D. In China, the coefficient was >0.7 between Cd-B and Cd-D. Furthermore, correlation was significant for Cd-B and Cd-D, as well as Cd-U and Cd-D, when 19 sets for Japan, Korea and China were combined for analysis. Discussion Major reasons for successful analysis may be predominant use of women-based data. Women have been less smoking than men in East Asia, and possible confounding effects of smoking on Cd exposure might be minimized. Conclusion Based on significant correlations, Cd-D can be estimated from Cd-B or Cd-U in East Asia.