69: Potential Interaction Between Midodrine and Linezolid

POTENTIAL INTERACTION BETWEEN MIDODRINE AND LINEZOLID Ramy Fayad, Jerry Yee, Nizar Attallah; Division of Nephrology and Hypertension, Henry Ford Hospital; Detroit, Michigan (USA) Linezolid is an oxazolidinone antimicrobial agent. Given its activity against resistant gram positive strains, it has gained widespread use in the dialysis patient population for treatment of catheter-related infections. In addition to its antimicrobial activity, linezolid is also known to have an inherent reversible monoamine oxidase inhibitor activity. Most of its side effects have been found to be-related to the gastrointestinal tract. In addition to headache, its side effects mainly include diarrhea, nausea and vomiting. Interactions between linezolid and selective serotonin reuptake inhibitors leading to a serotonin syndrome have been reported in the literature. Despite the theoretical dopaminergic potentiation of adrenergic agents by linezolid, such interactions have not yet been reported.