Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

AbstractContext: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.Objective: The aim of this review was to summarize biomarkers of SAH associated with outcome.Methods: An electronic database query was completed, including an additional review of reference lists to include all potential human studies.Results: A total of 298 articles were identified; 112 were reviewed; 55 studies were included.Conclusion: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.