Edge prior guided dictionary learning for quantitative susceptibility mapping reconstruction

Background: Compared with conventional magnetic resonance imaging methods, the quantitative magnetic susceptibility mapping (QSM) technique can quantitatively measure the magnetic susceptibility distribution of tissues, which has an important clinical application value in the investigations of brain micro-bleeds, Parkinson's, and liver iron deposition, etc. However, the quantitative susceptibility mapping algorithm is an ill-posed inverse problem due to the near-zero value in the dipole kernel, and high-quality QSM reconstruction with effective streaking artifact suppression remains a challenge. In recent years, the performance of sparse representation has been well validated in improving magnetic resonance image (MRI) reconstruction. Methods: In this study, by incorporating feature learning into sparse representation, we propose an edge prior guided dictionary learning-based reconstruction method for the dipole inversion in quantitative susceptibility mapping reconstruction. The structure feature dictionary relies on magnitude images for susceptibility maps have similar structures with magnitude images, and this structure feature dictionary and edge prior information are used in the dipole inversion step. Results: The performance of the proposed algorithm is assessed through in vivo human brain clinical data, leading to high-quality susceptibility maps with improved streaking artifact suppression, structural recovery, and quantitative metrics. Conclusions: The proposed edge prior guided dictionary learning method for dipole inversion in QSM achieves improved performance in streaking artifacts suppression, structural recovery and deep gray matter reconstruction.