REVIEWS IN MEDICINE

Chemotherapy has been used to treat a multitude of eye cancers. We attempted to review the role of chemotherapy in the treatment of ocular, adnexal, and orbital malignancies by conducting an extensive search of the medical literature. Unfortunately, the published reports typically contain few patients with limited follow-up, precluding definitive recommendations. For most eye cancers, multi- center trials will offer the potential to gather the numbers of patients required to determine the clinical utility of chemotherapy. ( Surv Ophthalmol 45 :416-444, 2001. © 2001 by Elsevier Science Inc. All rights reserved.)