Freeze Concentration with Ice-Lining in a Crystallizer of Agitated Vessel

A new method of freeze concentration with ice-lining has been developed, in which concentration of the solution can be performed only through the growth of an ice layer pre-coated on the inner wall of a crystallizer of agitated vessel with cooling jacket. From the measurements of concentration and volume of the residual solution during freezing process of cphalosporin C sodium solution, it was revealed that this method has an excellent superiority in recovery of high concentrate to the simple method without ice-lining.