Complement activation and regulation in early and advanced stage osteoarthritis

Although not considered a classical inflammatory arthropathy, osteoarthritis (OA) is often associated with lowgrade synovitis. The stimuli required to establish inflammation in OA synovium are as yet unclear, but there is emerging evidence to suggest activation of the complement pathway may have a role in this process. The aim of this study is to better describe the role that complement activation may play in the establishment or perpetuation of synovial inflammation in early and advanced OA. …