Comparative Study of Nucleophilic am) Enzymic Reactions of 2-Propyl Methylphosphonate Derivatives

Abstract Solvent isotope effects have been measured for the reactions of 4-nitrophenyl 2-propyl methylphosphonate (IMN) with acetylcholinesterase (AChE), chymotrypsin, imidazole base, hydroxide ion, phosphate dianion, and water, and for the reactions of 2-propyl methyl phosphonofluoridate (sarin) with AChE. Kinetics and structural features of the dealkylation of AChE and chymotrypsin adducts were also studied.