The effects of estradiol valerate plus medroxyprogesterone acetate and conjugated estrogens plus medrogestone on climacteric symptoms and metabolic variables in perimenopausal women

Background. Two sequential hormone replacement regimens, containing either estradiol valerate plus medroxyprogesterone acetate (E2V/MPA) or conjugated estrogens plus medrogestone (CE/MED). were compared with respect to effects on climacteric symptoms, lipid metabolism, and hemostasis.Methods. In an open, multicenter study. 51 perimenopausal women were randomized to E2V/ MPA and 50 to CE/MED. Assessment of climacteric complaints was performed at baseline and at months 1, 3. and 6. The effects on lipid and hemostatic variables were measured at baseline and at month 6. Quantitative data were analyzed using analysis of variance, the paired t-test, or the χ2 Mantel-Hanszel test, where appropriate.Results. Efficacy regarding treatment of climacteric symptoms was with E2V/MPA as good as with CE/MED. with a statistically significant reduction of most symptoms in both groups. After 6 months, total cholesterol and triglycerides had remained unchanged in both groups. High-density lipoprotein cholesterol showed no si...