Identification of the parameters of a glucose/insulin control model based on individually monitored self-control data in diabetes care

Intensified diabetes treatment including education and training in self-management of blood glucose control has become a permanent task for all people involved in diabetes care, To support this process the interactive computer program KADIS(R) (Karlsburger Diabetes Management System) has been developed and realised. The entire program comprises tools for handling of the self-control data, for automatic adjustment of the program to the individual self-control data of a given patient, and for model-based prediction of the apparent effects of self selected therapeutic measures on the 24 h-blood glucose profiles. To enable easy handling of the program without any special experience in medical informatics, KADIS(R) comprises also a problem-oriented knowledge base to visualise dose- and time-dependent-action profiles of therapeutically administered insulin formulations, of dose-dependent resorption profiles of various foodstuffs, and of dose- and time-dependent profiles of insulin action equivalents of exercise. The feasibility and acceptance of the prototype version of the program which is written in DELPHI/sup R/ was successfully tested in 43 young diabetic children of either sex during a summer camp.