The Role of Aspirin in Thrombotic Thrombocytopenic Purpura: A Randomized Control Trial

Method: Nine patients with TTP admitted between August 2003 to December 2005 were included in the study. Seven were females (77.8%) and one was pregnant. Five Patients were randomized to receive the standard therapy with aspirin (group I) and four (group II/control) received the standard therapy only (plasma exchange, one single plasma volume daily using fresh frozen plasma from healthy donors and Methylprednisolone 1 gram intravenously once daily for three days). Safety and efficacy of aspirin were assessed during the acute phase (4 weeks) and as maintenance for one year.