Effects of ulinastatin on inflammatory factors in patients after chemotherapy during one lung ventilation

To investigate the effects of ulinastatin on inflammatory factors in patients after chemotherapy during one lung ventilation. Thirty patients with lung cancer after chemotherapy for selective pulmonary surgery(ASA II-III) were selected and were randomly divided into two groups: control group (group C,n = 15) and ulinastatin group (group U,n=15). Group U: Patients received ulinastatin 10000 U·kg~(-1), iv after induction of anesthesia. Group C: Patients received equal volume of normal saline instead of ulinastatin. Blood concentrations of IL-8 and IL-10 from peripheral vein were determined after induction of anesthesia (S_(1)),40 min after one-lung ventilation in the lateral position (S_(2)),90 min after one-lung ventilation in the lateral position (S_(3)),30 min after two-lung ventilation at the end of the operation (S_(4)); 24 h after operation (S_(5)). Plasma IL-8 concentrations increased significantly at S_(3-5) in both group as compared with the baseline values and were significantly lower at S_(3-4) in ulinastatin group than in group C (P<0.05). Plasma IL-10 mass concentrations increased significantly at S_(3-5) in both groups and were significantly hegher at S_(3-4) in ulinastatin group than in group C (P<0.05). Ulinastatin can effectively decrease the level of plasma IL-8 and upgrade the level of plasma IL-10 in the patients after chemotherapy.