Progress in the biomarkers of perioperative neurocognitive dysfunction

The suppression of nerve cells by surgery and anesthesia has long been considered to be transient and reversible. However, with the development of clinical research, it has been confirmed that surgery and anesthesia may cause neurological sequelae to various degrees. Perioperative neurocognitive dysfunction (PNCD) is one of the common surgical complications. Despite the improvement of clinical diagnosis and treatment in China, the incidence of PNCD has not been effectively improved, and the disease has drawn increasing scientific attentions. Currently, the pathogenesis of PNCD is still not completely clear, but some evidence indicates the relationship between some biomarkers and PNCD. Key words: Perioperative neurocognitive dysfunction; Biomarkers