SAT0549 SARCOPENIA IN RHEUMATOID ARTHRITIS FEMALE PATIENTS: RELATIONSHIP BETWEEN WHOLE BODY AND TRABECULAR BONE SCORE

Background: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis and an increased risk of fractures. Sarcopenia is a syndrome in which muscle mass loss is linked to functional loss.Trabecular Bone Score (TBS), is an index extracted from the dual-energy X-ray absorptiometry (DXA) that provides an indirect measurement of bone axial microarchitecture and allows to get information about bone quality [1-3]. Objectives: The aims of this study were to examine associations between bone mineral density, bone quality, fat mass and lean mass in the whole body in female patients with RA and healthy controls (CNT). Methods: 55 female patients (mean age 58±12 years) affected by RA and 55 CNT (mean age 52±16 years) were enrolled. Bone Mineral Density (BMD, g/cm 2) of the lumbar spine (L1-L4) and whole body expressed by Relative skeletal mass index (RSMI) was analyzed using a DXA scan (GE, Lunar Prodigy). Lumbar spine TBS was derived for each spine DXA examination using the TBS index (TBS iNsight Medimaps).For all subject was calculate the Body Mass Index (BMI, kg/m2). According to the anthropometric equation [4], sarcopenia was defined as RSMI Results: The mean BMD±SD compared by RA and CNT was 0.894±0.127 g/cm2 vs 1.298±0.672 g/cm2 at the lumbar spine and 0.694±0.842 g/cm2 vs 1.132±0.998 g/cm2 on total hip, respectively, all p Conclusion: This study show that sarcopenia is frequent in RA patients, mostly on those classified as normal or overweight according to BMI. Therefore TBS and BMD values, as demonstrated could have a key role in a bone-muscle feedback in chronic systemic inflammatory rheumatic diseases, such as RA. References [1] Cutolo M et al. Autoimmun Rev 2011:12;84-7 2. Ruaro B, Casabella A, et al. Rheumatology (Oxford). 2018;57:1548-1554. 3.Ruaro B, Casabella A, et al. Rheumatology (Oxford). 2018;57:1548-1554 4. Baumgartner RN et al., J Epidemiol. 147:755–763 Disclosure of Interests: None declared