[18F]FDG PET signal is driven by astroglial glutamate transport

The identity of the cell types contributing to the [18F]FDG positron emission tomography signal remain highly controversial. In this study, the authors demonstrate that activating glutamate astrocytic transport increases brain [18F]FDG uptake. These findings indicate that astrocytes may also impact [18F]FDG positron emission tomography signal.