Anti-erythema and anti-edema activities of lactic acid bacteria extracts in mice

We examined the anti-inflammatory activities of 10 lactic acid bacteria extracts, obtained by lysozyme treatment. Among ferments of the 10 species, Bifidobacterium lactis showed the highest anti-erythema (73.4%) and anti-edema (67.1%) effects. When comparing the anti-inflammatory activities of fermented broth and lactic acid bacteria in fermentation broth, the anti-erythema effect (70.4%) of 37.5 μg B. lactis hydrolysate, hydrolyzed enzymatically with 2.0 mg/mL lysozyme, was superior to that of the supernatant (68.5%). The anti-edema effect (74.2%) of 50 μg B. lactis hydrolysate, hydrolyzed enzymatically with 2.0 mg/mL lysozyme, was superior to that of the supernatant (68.5%). These results suggest that B. lactis hydrolysate may be useful as a source of anti-inflammatory agents for dermal applications.