Novel Tenascin-C Haplotype Modifies the Risk for a Failure to Heal After Rotator Cuff Repair

Background:Several single-nucleotide polymorphisms (SNPs) in the TNC gene have recently been found to be associated with degenerative rotator cuff tears.Hypothesis:Exonic SNPs in the TNC gene are related to the risk for a failure to heal after rotator cuff repair.Study Design:Case-control study; Level of evidence, 3.Methods:A total of 302 patients from the Vienna area and European Caucasian ancestry underwent mini-open rotator cuff repair for a full-thickness superior or posterosuperior tear and were assessed for the integrity of the repair 1 year postoperatively with a real-time 7.5- to 10-MHz ultrasound linear array transducer. Outcomes were classified as intact (complete footprint coverage), small (<200 mm2), or large (≥200 mm2) recurrent defect. Patients were genotyped for 15 previously identified risk SNPs within a 49-kbp segment of the TNC gene with the KASP genotyping technology or the Ion-Torrent Personal Genome Machine System.Results:All recurrent defects were atraumatic failures, and the overall...