Microwave induced synthesis, characterization and antitumor activities of some bis-(3,5-diaryl-2 -pyrazolin1-yl)methanes
2009
(3,5yl)methanes were prepared by condensation of 3,5-diaryl-2-pyrazolines with formaldehyde under microwave irradiation condition. Antitumor activity of synthesized compounds was evaluated by estimating the effect of these compounds on the growth of cells. Breast adenocarcinoma (MCF-7), mammary cancer (EVSA-7) and gastrointestinal cell lines (HepG-2) were used. Four compounds have shown inhibition for HepG-2 cancer growth, three compounds were active against EVSA-7 cancer cells.
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