IN VITRO ACTIVITY OF CHLORHEXIDINE GLUCONATE AGAINST METHICILLIN-RESISTANT AND -SENSITIVE STAPHYLOCOCCUS AUREUS STRAINS
2013
A wide variety of antimicrobial cationic agents, such as chlorhexidine
gluconate, are commonly used in antiseptic preparations in the prevention of
nosocomial infections caused by methicillin-resistant Staphylococcus aureus
(MRSA). In this study was investigated the activity of chlorhexidine
gluconate against MRSA and methicillin-sensitive Staphylococcus aureus
(MSSA). The quantitative suspension test was carried out with 1% and 4%
chlorhexidine gluconate and contact time of 30 s, 60 s and 120 s. Since the
plasmid-borne gene qacA/B confers resistance to cationic antiseptic agents in
S. aureus, activity was also examined with regard to the presence of qacA/B.
The results indicate that neither 1% nor 4% chlorhexidine gluconate achieved
a log10 reduction factors (RF) >5 against MRSA and MSSA strains at 30 s, 60 s
and 120 s. At all concentrations, the RF for MRSA qacA/B negative strains
were significantly higher when compared to MRSA qacA/B positive strains at 60
s and 120s.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
17
References
0
Citations
NaN
KQI