Abstract MP59: Associations of Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain with Offspring Longitudinal Change in BMI

Introduction A number of studies have demonstrated significant associations between changes in obesity-related phenotypes and subsequent risk of CHD. While accumulating evidence suggests that maternal pre-pregnancy body mass index (mppBMI) and gestational weight gain (GWG) may impact adult offspring adiposity, no study has examined their associations with longitudinal changes in obesity. Changes in obesity are likely to reflect genetic-environmental interactions and may have important implications for understanding CHD risk. Objectives We examined the associations of mppBMI and GWG with longitudinal change in offspring’s BMI and assessed whether these associations are explained in part by genetic effects. Methods We used a birth cohort of 1400 young adults born in Jerusalem, with extensive archival data as well as clinical information at age 32, and longitudinal change in BMI based on two examinations at ages 17 and 32. Genotyping of mothers and offspring was carried out for 180 candidate genes related to...