Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-L-amino acid dianion.

Abstract Eight novel platinum(II)/palladium(II) complexes with 1,3-dap and 4-toluensulfonyl- l -amino acid dianion, [Pt(1,3-dap)(TsalaNO)]·0.5H 2 O ( 1a ), [Pt(1,3-dap)(TsvalNO)] ( 1b ), [Pt(1,3-dap)(TspheNO)] ( 1c ), [Pt(1,3-dap)(TsserNO)] ( 1d ), [Pd(1,3-dap)(TsalaNO)]·1.5H 2 O ( 2a ), [Pd(1,3-dap)(TsvalNO)] ( 2b ), [Pd(1,3-dap)(TspheNO)] ( 2c ) and [Pd(1,3-dap)(TsileNO)] ( 2d ) have been synthesized and characterized by elemental analysis, IR, UV, 1 H NMR and mass spectrometry techniques. Crystal structure of the complex 1b has been determined by X-ray diffraction. The cytotoxicity was tested by MTT and SRB assays. The complexes ( 1a – 1d and 2a – 2d ) exert cytotoxicity against Bel-7402, HL-60, KB and BGC-823, but none of them is more active than cisplatin. The results suggest that metal ions, amino acids and aliphatic N-containing ligands have effect on cytotoxicity, while the IC 50 values do not show definite correlation with variation of them.