Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
2016
DNA methylation in human brain shows dramatic variation across development. Genetic loci implicated in risk for schizophrenia are enriched for epigenetic states that show changes from the transition from prenatal to postnatal life. These findings suggest that early development is involved in both genetic and environmental risk factors for schizophrenia.
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