Procedure enzymatic synthesis of (7S) -1- (3,4-dimethoxy-bicyclo [4.2.0] octa-1,3,5-trien-7-yl) N-metilmetanoamina and their use in the synthesis of ivabradine and you go out

Synthesis method of the compound of formula (IX): where R 1 represents ** ** Formula a (C1-C6) alkyl, allyl or benzyl, by enantioselective enzymatic acylation of the racemic amine of formula (IV): ** ** formula using a lipase (EC 3.1.1.3 in the international enzyme classification): with a carbonate of formula R 1 O- (CO) -OR1donde R1 has the meaning defined above, in an amount having from 1 to 15 molar equivalents relative to the amine of formula (IV) in an organic solvent, aqueous, a mixture of organic solvents or a mixture of organic and aqueous solvents at a concentration of 5 to 500 g / l of the compound of formula (IV ) per liter of solvent or solvent mixture, in an E / S ratio of 10/1 to 1/100, at a temperature of 25 to 40.