Abstract 16826: Older Adults With Unrecognized Myocardial Infarction Have Increased Risk of Heart Failure

Background: Heart failure (HF) is an important cause of morbidity and mortality in older populations. In this study we characterized the risk of HF in relation to unrecognized myocardial infarction (UMI) among those without prevalent cardiovascular disease (CVD) in an elderly cohort. Methods: The study subjects were the participants of the Iceland_MI substudy of the Age, Gene/Environment Susceptibility-Reykjavik study, a population based prospective study of older adults. We excluded subjects with prevalent CVD defined as a history of recognized MI, acute coronary syndrome, HF, cardiac arrest, ventricular arrhythmia and stroke. Left ventricular ejection fraction (LVEF) was assessed using cine MRI and UMI was determined by late gadolinium enhancement imaging. Incident HF was adjudicated based on medical records. Results: Of the 701 subjects analyzed, the mean age was 77±5 years, 57% were female and 34% diabetic. The prevalence of UMI was inversely related to the LVEF, 50%, 24% and 10% for LVEF≤45% (n=26) L...