Dental health in advanced age and Alzheimer's Disease: A possible link with bacterial toxins entering the brain?

Abstract We investigated a possible link between bacterial infestation of the oral cavity, dental health and Alzheimer's dementia (AD). Resistant germs on the surface of the maxillary molars are the cause of a complex biofilm of bacteria with the effect of a colonization of germs between oral cavity and maxillary sinus. Bacterial toxins may lead to subsequent inflammatory processes transgressing to neighboring central nervous system structures that are suspected to be crucial in the inception of AD, such as the entorhinal cortex and the hippocampus.