Synthesis and Biological Evaluation of KRIBB3 Analogues on a Proliferation of HCT-116 Colorectal Cancer Cells

Therefore, the development of can cer therapy targeted to cyto-toxicity is still important. Cell cycle control is the major regula-tory mechanism of cell growth. Small chemicals that inhibit cell cycle progression have attr acted much attention for cancer therapy because they can block tumor growth. Drug-mediated mitotic-checkpoint-dependent-arrest is often followed by cell death.