Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke

OSTEOGENIC protein-1 (OP-1, BMP-7) is a member of the transforming growth factor-β (TGF-β) superfamily that selectively induces dendritic outgrowth from cultured neurons. We injected human recombinant OP-i1(1 or 10 μg) or vehicle into the cisterna magna of mature male Sprague-Dawley rats 1 and 4 days after focal cerebral infarction induced by middle cerebral artery (MCA) occlusion. OP-1 treatment was associated with a marked enhancement of recovery of sensorimotor function of the impaired forelimb and hindlimb (contralateral to infarcts) as assessed by limb placing tests. This effect appeared to be dose dependent. There was no difference in infarct volume between OP-1 and vehicle-treated rats. The mechanisms of enhanced recovery by intracisternal OP-1 may include promotion of dendritic sprouting in the intact uninjured brain.