1α,25-dihydroxyvitamin D3-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression

Jiang Jiang,Yang Zhang,Arup K. Indra,Gitali Ganguli-Indra,Mai N. Le,Hongjun Wang,Ronald Ray Hollins,Debra Reilly,Mark A. Carlson,Richard L. Gallo,Adrian F. Gombart,Jingwei Xie

1α,25-dihydroxyvitamin D3-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression

2018

Jiang Jiang
Yang Zhang
Arup K. Indra
Gitali Ganguli-Indra
Mai N. Le
Hongjun Wang
Ronald Ray Hollins
Debra Reilly
Mark A. Carlson
Richard L. Gallo
Adrian F. Gombart
Jingwei Xie

Aim: The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and augmenting human CAMP induction.

Keywords:

Molecular biology
Materials science
Innate immune system
Antimicrobial
Endogeny
Peptide
Ex vivo
Nanofiber
HaCaT
Antimicrobial peptide production
In vitro
In vivo
Human skin

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