Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury
2014
Purpose
Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated the importance of histone modifications.
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