Diagnostic and prognostic value of endothelin-1 plasma concentrations in dogs with heart and respiratory disorders.

2006 
The endothelin-1 (ET-1) plasma concentration was measured in dogs with spontaneous cardiac or respiratory diseases. Plasma samples were obtained from 76 healthy control dogs and 73 dogs, of which 58 were suffering from heart disease and 15 were suffering from respiratory disease. Dogs were evaluated using echocardiography, thoracic radiography, biochemical evaluation and a radioimmunoassay for ET-1. ET-1 plasma concentrations were significantly higher in dogs with spontaneous cardiac or respiratory diseases (mean [se] 5·3 [0·3] and 5·3 [0·6] pg/ml, respectively) than in healthy dogs (1·9 [0·1] pg/ml) (P
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