Overexpression of DHX32 contributes to the growth and metastasis of colorectal

Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to itsadjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largelyunknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells.Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration, and invasion, as well asdecreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analysesrevealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of WISP1, MMP7andVEGFAin the Wnt pathway, and anti-apoptotic gene BCL2and CA9, however, elevated expression ofpro-apoptotic geneACSL5.ThefindingssuggestedthatoverexpressedDHX32playedanimportantroleinCRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a noveltherapeutic target for CRC.