Infección orofacial por Conidiobolus coronatus reporte de caso

Entomophtoramycosis is a kind of subcutaneous mycosis, include both basidiobolomycosis and conidiobolomycosis; last one is caused by Conidiobolus coronatus a saprophytic fungus that inhabits of the soil of the tropical countries. Typically this mycosis involves rhinofacial, soft tissues of the face, sinuses and oropharynx, with a potential capacity of deforming. Usually it’s happening in immunocompetent patients and it has a chronic course and in the histology granulomas are shaped. We report the case of a 28-year-old farmer with a clinical picture of 6 months of evolution of rhinofacial swelling, nasal obstruction and subsequent runoff; Diagnosis of conodiobolomycoses was made through tissue culture after multiple biopsies of the facial area. He received antifungal treatment with amphotericin B and after were changed by itraconazole with dramatic improvement without requiring surgery, treatment was extended for one year and at the end there was no evidence of relapse. There is no clear strategy of treatment because of the low frequency of this disease, however the use of azoles such as itraconazole is increasing with or without adjuvant surgical treatment. This case report is attached to the clinical experience in Colombia about this rare mycosis and describes the clinical and therapeutic response to long time.