Hemato-biochemical and pathological alterations of chronic nephritis in a dog

The present study was carried out to investigate the haemato-biochemical, gross and histopathological changes of chronic nephritis in a dog. Decreased value of Hb, PCV, TEC and platelat counts were observed in haematological evaluation. Increase value of BUN and creatinine was found in biochemical estimation. On necropsy, the kidneys were reduced in size and after removal of the capsule cortex showed an uneven and pitted appearance with multifocal petecheal haemorrhages. Histopathological examination revealed different stages of tubular degeneration and necrosis, widening of the bowman’s space, decrease glomarular cellularity, presence of infiltrating cells predominantly lymphocytes and plasma cells. Other histopathological findings include focal area of fibrosis, dystrophic calcification, vascular congestion and focal hemarrhages in the interstitial spaces.