A case of myofibromatosis of the mandible

A very rare case of multinodular myofibromatosis involving a wide area of the mandible is presented. Myofibromatosis is a benign localized or generalized proliferation of fibroblastic tissue occurring exclusively in infants or children. Most lesions are recognized as dermal or subcutaneous nodules, but lesions rarely develop in the skeleton or internal organs. Our patient was a 15-year-old girl with buccal and submandibular swelling. Roentgenographic examination revealed a large well-demarcated radiolucent area. Segmental resection of the mandible was performed, and follow-up showed no evidence of recurrence. Microscopically, the tumor was multinodular and surrounded by a fibrous capsule. It was characterized by irregular fascicles of fibrous tissue alternating with a central hemangiopericytoma-like pattern.