Landscape of DNA-damage-repair/homologous recombination deficiency (DDR/HRD) in hepatopancreaticobiliary (HPB) cancers.

Wungki Park,Ethan Sokol,Jiapeng Chen,Kenneth H. Yu,Danny N. Khalil,James J. Harding,Imane El-Dika,Nadeem Riaz,Ghassan K. Abou-Alfa,David P. Kelsen,Christine A. Iacobuzio-Donahue,Eileen M. O’Reilly

Landscape of DNA-damage-repair/homologous recombination deficiency (DDR/HRD) in hepatopancreaticobiliary (HPB) cancers.

2020

Wungki Park
Ethan Sokol
Jiapeng Chen
Kenneth H. Yu
Danny N. Khalil
James J. Harding
Imane El-Dika
Nadeem Riaz
Ghassan K. Abou-Alfa
David P. Kelsen
Christine A. Iacobuzio-Donahue
Eileen M. O’Reilly

4620Background: Biallelic HR-gene mutations (HRm) confer HRD and sensitivity to DDR-targeted therapies including platinum and PARPi in pancreatic cancer (PDAC). The landscape of DDR/HRD phenotypes ...

Keywords:

Homologous Recombination Deficiency
DNA Damage Repair
Pathology
Cancer research
Medicine

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