The structural connectome and internalizing and externalizing symptoms at 7 and 13 years in individuals born very preterm and full-term.

ABSTRACT Background Children born very preterm (VP) are at higher risk of emotional and behavioral problems compared with full-term (FT) children. We investigated the neurobiological basis of internalizing and externalizing symptoms in individuals born VP and FT by applying a graph theory approach. Methods Structural and diffusion MRI data were combined to generate structural connectomes and calculate measures of network integration and segregation at 7 (VP:72; FT:17) and 13 years (VP:125; FT:44). Internalizing and externalizing were assessed at 7 and 13 years using the Strengths and Difficulties Questionnaire. Linear regression models were used to relate network measures and internalizing and externalizing symptoms concurrently at 7 and 13 years. Results Lower network integration (characteristic path length and global efficiency) was associated with higher internalizing symptoms in VP and FT children at 7 years, but not at 13 years. The association between network integration (characteristic path length) and externalizing symptoms at 7 years was weaker, but there was some evidence for differential associations between groups, with lower integration in the VP and higher integration in the FT group associated with higher externalizing symptoms. At 13 years, there was some evidence that associations between network segregation (average clustering coefficient, transitivity, local efficiency) and externalizing differed between the VP and FT groups, with stronger positive associations in the VP group. Conclusions This study provides insights into the neurobiological basis of emotional and behavioral problems following preterm birth, highlighting the role of the structural connectome in internalizing and externalizing symptoms in childhood and adolescence.