Analysis of reasons for elimination of 13 705 sperm donors in the Human Sperm Bank of Guangdong Province

Objective To analyze the reasons for the elimination of human sperm bank volunteers in order to promote the standardized screening of human sperm bank volunteers, and improve the quality of screening. Methods A retrospective analysis was done on the screening data of all 13 705 sperm donors recruited by Guangdong Human Sperm Bank from its establishment in 2003 to 2017. Results During the screening period, 80.5% of the volunteers had one semen test and 19.5% had two semen tests. A total of 54.7% (7498/13 705) of the volunteers were eliminated because the quality of semen did not meet the standard of sperm donation; 45.3% (6207/13 705) of the volunteers were screened for semen quality to meet the standard of sperm donation and then examined for infectious diseases, sexually transmitted diseases and genetic diseases. A total of 4160 eligible volunteers were screened and accounted for 30.3%. A total of 2047 volunteers were eliminated by laboratory test results, accounting for 33%. The reasons for elimination were as follows: 4.14% (257/6207) HBsAg positive, 0.19% (12/6207) hepatitis C antibody positive, 0.11% (7/6207) syphilis antibody positive, 0.03% (2/6207) HIV antibody positive, 3.63% (225/6207) eugenic four antibodies positive, 0.14% (9/6207) Chlamydia positive, 6.61% (410/6207) Mycoplasma positive, 0.03% (2/6207) were positive for gonorrhea, 0.27% (17/6207) for pathogenic bacteria, 11.64% (722/6207) for thalassemia screening, 4.29% (266/6207) for G6PD enzyme deficiency, and 1.92% (118/6207) for chromosomal abnormalities. Conclusion The positive rate of pathogen screening in sperm donation volunteers was lower than that in the general population, so human sperm bank must strictly grasp the principle of volunteer elimination, and strengthen the publicity and education of volunteer recruitment. Key words: Sperm bank; Volunteers; Screening; Elimination; Laboratory examination