An Improvement in Synthesis of Intermediate of Pitavastatin Cacium

This method is improved for preparing the intermediate of pitavastatin calcium by the reaction of L-(-)-malic acid through methyl esterification,selective reduction,trityl protection,Claisen condensation,stereoselective reduction,ketalization,deprotection of trityl and Swern oxidation.The total yield is 21.2%.This method reduced the production cost,enhanced yield,and suits for industrial production.