PD18-05 XPERTBLADDER MONITOR TEST FOR FAILURE DEFINITION OF PATIENTS UNDER ACTIVE SURVEILLANCE FOR RECURRENT LOW-RISK NON-MUSCLE INVASIVE BLADDER CANCER (NMIBC) WITH NEGATIVE CITOLOGY

INTRODUCTION AND OBJECTIVES:Active surveillance (AS) has been showed to be feasible and effective in a sub-set of patients with recurrent low-grade non-muscle invasive bladder cancer (LG-NMIBC). Xpert BC Monitor is a new mRNA-marker test for BC follow-up, which measures the levels of five target mRNAs from a voided urine sample by real-time RT- PCR. The aim of this study was to test the hypothesis that Xpert Bladder monitor test may improve the diagnosis of failure and avoid unnecessary TURBT in patients under AS.METHODS:This is a prospective observational cohort study of patients with a previous pathologically confirmed NMIBC, who experienced recurrence during follow-up and accepted to undergo AS according to the Bladder Cancer Italian Active Surveillance project (BIAS_ICH_V1.2_27.01.2018). in addition to urine cytology, urinary samples were analysed using Xpert BC Monitor (Cepheid, Sunnyvale, CA, USA) at each follow-up or at entry in case of a new episode of AS, measuring the gene expression levels of f...