The relevance of oxidative stress balance (Superoxide dismutase versus malondialdehyde) in spontaneous bacterial peritonitis
2014
Among bacterial infections associated with hepatic cirrhosis, the most common
is spontaneous bacterial peritonitis (SBP). Despite different protective
measures, such as early diagnosis, therapy with albumin and the introduction
of new antibiotics, the prognosis of these patients remains poor, with a
mortality rate of 20-40%. In this context, the identification of patients
with increased risk of death is extremely important for improving the
prognosis. Thus, there is growing interest for studying the effects and
mechanisms of oxidative stress, considering the requirements for identifying
new substances with hepatoprotective functions and reducing various adverse
effects. In this study, we assessed oxidative stress markers, the antioxidant
enzyme superoxide dismutase (SOD) and the marker of lipid peroxidation,
malondialdehyde (MDA), in the serum and ascitic fluid in patients with
decompensated cirrhosis and SBP, in patients diagnosed with decompensated
liver cirrhosis with ascites and in patients with compensated liver
cirrhosis. Increased oxidative stress, demonstrated by a significant decrease
of SOD and increase in MDA levels, was observed in patients with
decompensated cirrhosis and SBP, compared with those without SBS, as well as
those with compensated liver cirrhosis. Measuring these oxidative stress
markers could have a fundamental importance in the diagnosis, treatment and
follow-up of this liver pathology.
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