Immunization with Thyroglobulin-Specific Cytotoxic T Cell Hybridoma Induces Anti-thyroglobulin Antibodies: Characteristics of Monoclonal Anti-thyroglobulin Auto-antibody

Abstract We have produced five monoclonal autoantibodies (mA-Abs) to thyroglobulin (Tg) and more precisely to one epitope located within the in vivo was further demonstrated and defined in vitro at the single cell level. Competitive studies for binding to pTg or to the -7 M order of magnitude). The results strengthen the hypothesis that T and B cells sharing the same specificity can express similar idiotopes on their respective receptors for antigen. They also demonstrate the existence of a regulatory idiotypic network that could explain the protection from EAT after injection of inactivated HTC2 cells or its anti-clonotypic mAb.