The changes in the permeability of the blood-brain barrier when under neurosurgical intervention

The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24–48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d.