Asymmetric synthesis of (S)-(−)-N-acetylcolchinol via Ullmann biaryl coupling

Abstract A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of ( S )-(−)- N -acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.