Synthesis and Dual Antagonistic Activity against Thromboxane A2 and Leukotriene D4 of (4-(1-(Benzenesulfonamido)alkyl)phenyl)alkanoic Acid Derivatives.

In order to find new antiasthmatic agents with dual antagonistic activity against thromboxane A 2 (TXA 2 ) and leukotriene D 4 (LTD 4 ) receptors, synthesis and pharmacological evaluation of various [4-[1-(benzenesulfonamido)-alkyl]phenyl]alkanoic acid derivatives were undertaken. TXA 2 and LTD 4 antagonistic activities in vitro were evaluated by measuring the inhibitory effects on U-46619-induced contraction of guinea-pig trachea and LTD 4 -induced contraction of guinea-pig ileum and trachea. Several compounds showed satisfactory dual antagonistic activities, and their effect (after oral administration) on LTD 4 -induced bronchoconstriction in guinea-pig in vivo was examined. The results demonstrated that both 4-[4-[l-(4-chlorobenzenesulfonamido)hexyl]phenyl]butyric acid (12e) and 4-[4-[1-(4-chlorobenzenesulfonamido)-5-methylhexyl]phenyl]butyric acid (12m) possessed good anti-LTD 4 activities. Compounds 12e and 12m were then evaluated for other related pharmacological effects involving the arachidonic acid cascade. These compounds appear to be hybrid eicosanoids antagonists having antagonistic activity against contraction of guinea-pig trachea induced by prostaglandin D 2 (PGD 2 ) and PGF 2α , as well as TXA 2 and LTD 4 antagonistic activities.