Studies on Peptides. XCV. Alternative Synthesis of Porcine Vasoactive Intestinal Polypeptide (VIP)
1980
Two alternative deprotecting procedures were employed for the synthesis of porcine vasoactive intestinal polypeptide (VIP). Besides HF, TFA-thioanisole was found to cleave all the protecting groups employed, Z, Bzl and Mts, suppressing a newly found side reaction, i.e., acid-catalyzed succinimide formation from Asp residues with the free carboxyl group. A small amount of the N-terminal His residue linked to Ser-Asp was found to be released on standing at pH 6.
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