Partners in Crime: Genes within an Amplicon Collude to Globally Deregulate Chromatin in Lymphoma

In this issue of Cancer Cell , Rui et al. identify JAK2 and JMJDC2 as two contiguous, coamplified oncogenes in primary mediastinal B cell and Hodgkin lymphoma. Together, JAK2 and JMJD2C induce major changes in chromatin structure and gene expression. Targeting these proteins with small molecules represents a new avenue for therapy.